John A Secrist Selected Research

fludarabine phosphate (Fludara)

1/2016	6-Methylpurine derived sugar modified nucleosides: Synthesis and in vivo antitumor activity in D54 tumor expressing M64V-Escherichia coli purine nucleoside phosphorylase.
1/2012	Preclinical antitumor activity of thiarabine in human leukemia and lymphoma xenograft models.
9/2004	Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene.
6/2004	Purine nucleoside antimetabolites in development for the treatment of cancer.

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John A Secrist Research Topics

Disease

23	Neoplasms (Cancer) 01/2020 - 03/2002
6	Leukemia 01/2012 - 09/2003
2	Hematologic Neoplasms (Hematological Malignancy) 01/2012 - 09/2004
2	Leukemia P388 01/2012 - 11/2011
2	Lymphoma (Lymphomas) 01/2012 - 01/2012
2	Infections 12/2009 - 09/2006
2	Glioma (Gliomas) 03/2005 - 09/2004
1	Hepatitis C 11/2012
1	Poxviridae Infections 02/2009
1	Colorectal Neoplasms (Colorectal Cancer) 01/2008
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2006

Drug/Important Bio-Agent (IBA)

9	NucleosidesIBA 01/2016 - 03/2003
7	ProdrugsIBA 04/2016 - 03/2002
5	Purine-Nucleoside PhosphorylaseIBA 01/2020 - 01/2003
5	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2012 - 03/2003
5	4'-thio-arabinofuranosylcytosineIBA 01/2012 - 03/2003
4	fludarabine phosphate (Fludara)FDA LinkGeneric 01/2016 - 06/2004
4	Clofarabine (Clolar)FDA Link 01/2012 - 10/2006
4	Pharmaceutical PreparationsIBA 08/2011 - 09/2003
3	Adenine FDA LinkGeneric 01/2020 - 01/2016
3	6-methylpurineIBA 01/2020 - 01/2016
3	Ganciclovir (Cytovene)FDA LinkGeneric 02/2010 - 03/2002
3	DNA (Deoxyribonucleic Acid)IBA 02/2010 - 09/2006
3	Purine NucleosidesIBA 01/2008 - 01/2003
2	EnzymesIBA 01/2016 - 03/2005
2	pyrimidineIBA 11/2012 - 05/2009
2	DeoxycytidineIBA 01/2012 - 09/2006
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2012 - 08/2011
2	Cisplatin (Platino)FDA LinkGeneric 01/2012 - 08/2011
2	2- amino- 1,9- dihydro- 9- (3- hydroxy- 4- (hydroxymethyl)cyclopentyl)- 6H- purine- 6- oneIBA 02/2010 - 03/2002
1	2-fluoroadenineIBA 01/2016
1	SugarsIBA 01/2016
1	deoxycytidine deaminaseIBA 01/2012
1	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2012
1	Antineoplastic Agents (Antineoplastics)IBA 01/2012
1	5'-palmitoyl cytarabine (PLAC)IBA 01/2012
1	Gemcitabine FDA Link 01/2012
1	Methotrexate (Mexate)FDA LinkGeneric 01/2012
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2012
1	Phosphotransferases (Kinase)IBA 01/2012
1	Cladribine FDA LinkGeneric 01/2012
1	CytidineIBA 01/2012
1	Doxorubicin (Adriamycin)FDA LinkGeneric 08/2011
1	Drug CombinationsIBA 08/2011
1	Etoposide (VP 16)FDA LinkGeneric 08/2011
1	Fluorouracil (Carac)FDA LinkGeneric 08/2011
1	CamptothecinIBA 08/2011
1	penciclovir (Denavir)FDA Link 02/2010
1	DeoxyguanosineIBA 02/2010
1	PurinesIBA 05/2009
1	CytosineIBA 05/2009
1	PolyaminesIBA 09/2007
1	VaccinesIBA 09/2006
1	Antiviral Agents (Antivirals)IBA 09/2006
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2005
1	AntimetabolitesIBA 06/2004
1	5-azacytosineIBA 12/2003
1	GuanosineIBA 09/2003
1	SulfurIBA 03/2003
1	fludarabineIBA 01/2003
1	purineIBA 01/2003
1	Thymidine KinaseIBA 03/2002

Therapy/Procedure

9	Therapeutics 01/2020 - 09/2004
1	TP protocol 01/2012
1	Radiotherapy 01/2008
1	Drug Therapy (Chemotherapy) 01/2008